Ibogaine Therapy: Forms and Dose Regimens Howard S. Lotsof,

Ibogaine Therapy: Forms and Dose Regimens Howard S. Lotsof, B.F.A., C.M.A. President Dora Weiner Foundation Staten Island, NY http://www.doraweiner.org

Forms in Current Use Botanical - root bark Total alkaloid extract purified ibogaine

Tabernanthe iboga shrub

Roots contain ibogaine

Total Alkaloid Extract Large piece 2cm x 2cm, approx 4 grams Estimate 15% ibogaine Courtesy Sara Glatt

Ibogaine HCl 99.4% purity

All forms have multiple treatment applications 1.Chemical use disorders 2.Pain management 3.Psychotherapy 4.Initiatory sessions

Each form has 1.Different onset 2.Different duration of action 3.And significant diversity across the patient population

Onset of Effects (min) 160 140 120 100 80 60 40 20 0 Full Effect Onset HCl Extract

Period of visuaization (hours) 16 14 12 10 8 6 4 2 0 Extended Visualization Onset HCl Extract

Duration of Action (days) 10 9 8 7 6 5 4 3 2 1 0 Residual Principal HCl Extract

Effect on sleep (weeks) 10 9 8 7 6 5 4 3 2 1 0 Residual Principal HCl

Dose and Dose Regimen 1.Single dose 2.Multiple 1.Escalating 2.Deescalating 3.Linear

All doses are representative. Doses, including single administration doses are determined on a patient by patient basis. The graphs of dose regimens and information that follow should not be used by persons without experience to self-administer or administer to others any dose of ibogaine or total alkaloid extract of Tabernanthe iboga.

Single dose regimens usually fall between 10mg/kg and 22mg/kg depending on type of therapy offered: opioid dependence, stimulant dependence, psychospiritual, etc. Most doses fall in the 15mg/kg - 20mg/kg dose range to reach full therapeutic effects.

ibogaine HCl (mg/hour) 20mg methadone total - 1000mg 400 350 300 250 200 150 100 50 0 350 175 175 0 h1 h2 175 h3 HCl 125 h4

ibogaine HCl (mg/kg/hour) stimulant therapy courtesy Eric Taub 16 14 12 10 8 6 4 2 10 3 2.5 0 HCl h2 h3

ibogaine HCl (mg/kg/hour) heroin therapy total 21.5mg.kg courtesy Eric Taub 16 14 12 10 8 6 4 2 14 HCl 5 2.5 0 1h h12

ibogaine HCl (mg/kg/hour) methadone therapy total 36.5 mg/kg courtesy Eric Taub 16 14 12 10 8 6 4 2 12 HCl 2.5 2.5 2.5 2.5 2.5 0 3 3 3 3 13 23 30 34 36 59 68 77 89 100

extract (grams/hour) heroin therapy total 7 grams courtesy Sara Glatt 6 5 4 3 2 1 0 3 Exract 3 1 0 12 36 48

extract (grams/hour/day) methadone therapy total 11 grams courtesy Sara Glatt 6 5 4 3 2 1 0 3 Exract 3 1 0 1 1 1 1 12 36 d2 d4 d6 d8 d10

extract (grams/hour) HCl (mg/hour) methadone 300mg/day total extract 9 grams total HCl 400mg courtesy Marc Emery 6 5 4 3 2 1 0 5.2 3.8 0.1 0 0.1 Exract HCl 0.1 0.1 h72 h96h120h168h192

All doses and dose regimens shown or discussed are representative and are not indicated to be provided to any other patient or subject. All doses and dose regimens are made on a patient by patient basis upon knowledge and prior art.