MAT 272/BMSE 272 Mechanical Force and Biomolecules: Lecture 1 Introduction: Why is force important for biomolecules? 1951: Pauling predicts alpha helix 1954: Watson and Crick propose double-helix Late 50s: Perutz, Kendrew attain first protein structures from X-ray crystallography 60s: Genetic code determined 70s: Amino acid sequences shown to uniquely determine protein function (Anfinsen) 80s: Biotechnology explodes (Molecular cloning , PCR) 90s: Genomes sequenced