HIV Life Cycle Boston University School of Social Work Center for

HIV Life Cycle Boston University School of Social Work Center for Innovation in Social Work & Health

HIV Life Cycle Objectives Boston University Slideshow Title Goes Here At the end of this unit participants will be able to: Describe the stages of HIV replication using the mnemonic AFRITAB Communicate how the HIV life cycle (VLC) works, how HIV enters the CD4 cell, replicates, and damages the immune system Identify the different classes of antiretroviral medications used for treatment of HIV Practice identifying antiretroviral medications by brand name, generic name, and abbreviation Demonstrate where each antiretroviral medication works to interrupt HIV replication

HIV Life Cycle Boston University Slideshow Title Goes Here ? What do you know about how HIV replicates inside the body?

HIV Life Cycle Think of a Fried Egg Boston University Slideshow Title Goes Here HOST CELL CD4 or T-cell The CD4 cell is the host cell for HIV. NUCLEUS The center of core of the CD4 cell. It contains DNA.

HIV Life Cycle RNA vs. DNA RNA Boston University Slideshow Title Goes Here HIV carries RNA Contains 1 strand of genetic information DNA Humans carry DNA Contains 2 strands of genetic information

HIV Life Cycle Boston University Slideshow Title Goes Here

HIV Life Cycle A Attachment Boston University Slideshow Title Goes Here F Fusion R Reverse transcription I Integration T Transcription A Assembly B Budding

HIV Life Cycle Boston University Slideshow Title Goes Here

HIV Life Cycle Boston University Slideshow Title Goes Here

HIV Life Cycle Boston University Slideshow Title Goes Here

HIV Life Cycle Boston University Slideshow Title Goes Here

HIV Life Cycle Boston University Slideshow Title Goes Here

HIV Life Cycle Boston University Slideshow Title Goes Here

HIV Life Cycle Boston University Slideshow Title Goes Here

HIV Life Cycle Boston University Slideshow Title Goes Here

Boston University Slideshow Title Goes Here ACTIVITY: HIV LIFE CYCLE

HIV Life Cycle: Medications at Work Boston University School of Social Work Center for Innovation in Social Work & Health

Medications at Work HIV Medications: The Early Days Boston University Slideshow Title Goes Here DATE MILESTONE 1987 1st medication, AZT was approved by FDA 1995 1st FDA approval of combination therapy 1996 1st Protease Inhibitor receives FDA approval Today 6 Classes of HIV medications; several single tablet, once a day regimens

Medications at Work HIV Medications: 3 Names Boston University Slideshow Title Goes Here HIV Medications are referred to by 3 names EXAMPLE 1 IV Medications: ThePrezista Basics Brand Name Generic Name Abbreviation EXAMPLE 2 Sustiva darunavir efavirenz DRV EFV 2017 HIV Drug Chart - Positively Aware

Medications at Work HIV Medication Classes Boston University Slideshow Title Goes Here There are 6 Classes of HIV medications: 1.NRTIs Nucleoside Reverse Transcriptase Inhibitors 2.NNRTIs Non-Nucleoside Reverse Transcriptase Inhibitors 3.PIs Protease Inhibitors 4.IIs Integrase Inhibitors 5.Entry Inhibitors 6.Boosters Pharmacokinetic Enhancers

Medications at Work Nucleoside Reverse Transcriptase Inhibitors (NRTIS) Boston University Slideshow Title Goes Here NRTIs Inhibit Reverse Transcription. Descovy Emtriva Epivir Epzicom Truvada Viread Ziagen

Medications at Work Non-nucleoside Reverse Transcriptase Inhibitors Boston University Slideshow Title Goes Here (NNRTIs) NNRTIs Inhibit Reverse Transcription. Edurant Intelence Sustiva

Medications at Work Protease Inhibitors (PIs) Boston University Slideshow Title Goes Here Protease Inhibitors help prevent the piecing together of HIV DNA into small “packages.” Evotaz Prezcobix Prezista Reyataz

Medications at Work Integrase Inhibitors (IIs) Boston University Slideshow Title Goes Here Integrase Inhibitors help to block HIV DNA from binding to the host cell DNA. Isentress Tivicay

Medications at Work Entry Inhibitors (Fusion Inhibitors) Boston University Slideshow Title Goes Here Fusion Inhibitors help to block HIV’s entry into the CD4 cell. Selzentry

Medications at Work Pharmacokinetic Enhancers (Boosters) Boston University Slideshow Title Goes Here Boosters are used to boost the effectiveness of another drug. Norvir Tybost

Medications at Work Once-daily HIV Medications Atripla (efavirenz, emtricitabine, tenofovir disoproxil fumarate) Boston University Slideshow Title Goes Here Biktarvy (bictegravir, tenofovir alafenamide, emtricitabine) Complera (rilpivirine, tenofovir, emtricitabine) Delstrigo (doravirine, tenofovir disoproxil fumarate, lamivudine) Genvoya (elvitegravir, cobicistat, emtricitabine, tenofovir alafenamide) Juluca (dolutegravir, rilpivirine) Odefsey (rilpivirine, tenofovir alafenamide, emtricitabine) Stribild (elvitegravir, cobicistat, tenofovir, emtricitabine) Triumeq (abacavir, dolutegravir, lamivudine) Symfi and Symfi Lo (efavirenz, lamivudine, tenofovir disoproxil fumarate) Symtuza (darunavir, cobicistat, emtricitabine, tenofovir alafenamide)

Medications at Work Activity: HIV Medications at Work Boston University Slideshow Title Goes Here Share the following: The name of the medication The drug class to which it belongs Locate the stage of replication where the medication interrupts HIV replication Example Selzentry Entry Inhibitor Selzentry stops HIV from entering the CD4 cell.